The Tampa Bay Rays selected Lorenzen in the seventh round of the 2010 Major League Baseball draft.

Lorenzen opted not to sign, and instead enrolled at California State University, Fullerton, to play baseball for the Titans.

He tried out for the Reds in spring training in 2015 as a relief pitcher[10] but was reassigned to the minor leagues before the start of the season.

[15] During spring training in 2016, he was diagnosed with a sprained ulnar collateral ligament in his right elbow,[16] and he did not return until mid-June.

He pitched out of the bullpen for Cincinnati upon his return, and he finished the year with a 2–1 record and a 2.88 ERA in 35 relief appearances.

Lorenzen was called up to pinch-hit in the seventh inning of a June 30, 2018, game against the Brewers and hit a grand slam off pitcher Jacob Barnes.

[17] During the 2018–2019 offseason, Lorenzen worked extensively as an outfielder and stated he had eagerness and desire for the transition to a two-way player.

[18] On September 4, 2019, Lorenzen became the second player in baseball history to hit a home run, earn the win as the pitcher, and play in the field in the same game when the Reds defeated the Phillies, 8–5.

[19] In 2020 for the Reds, Lorenzen pitched in 18 games, registering a 3–1 record and a 4.28 ERA with 35 strikeouts in 33+2⁄3 innings of work.

[24] He made his Angels debut on April 11, 2022, starting the game and pitching 6 innings with 2 hits and 1 earned run allowed while striking out 7 against the Miami Marlins.

[25] On May 1, 2022, Lorenzen made his longest career start against the Chicago White Sox, giving up 3 runs in 8+1⁄3 innings of work.

[30] He was activated off the injured list on April 15, 2023, to make his Tigers debut starting against the San Francisco Giants.

[33][34] On August 9, in his first home start in Philadelphia, with his mother, wife, and daughter in attendance, Lorenzen threw a no-hitter in a 7–0 win over the Washington Nationals.

[41] He took the loss in Game 1 of the American League Division Series, allowing one run and one inherited runner to score.

"[47] Lorenzen began experimenting with drugs and alcohol in eighth grade, but stopped when he was 17 after a man read him the Gospel.

In his first game back from the bereavement list on August 19, 2016, he hit his first career home run and dedicated it to his father.