In his first season, Mifsud made six appearances and scored once, helping Sliema Wanderers to a third-place finish in the Maltese Premier League.

He made 23 appearances and scored eight goals, as Sliema Wanderers again recorded a third-place finish in the Maltese Premier League.

The failure to secure the move to Manchester United did not affect Mifsud, who was in fine goalscoring form for Sliema Wanderers, netting 21 times in 28 outings.

Mifsud helped the club to a second-place finish in the Maltese Premier League, making 25 appearances and scoring an impressive 20 goals.

[1] Mifsud failed to make the grade with Kaiserslautern A team and his wish for regular first-team football meant he was released in the winter of 2004.

Mifsud went on to make 12 appearances and score eight goals, helping Sliema Wanderers to retain the Maltese Premier League title.

The previous summer, Lillestrøm had turned down an offer for Mifsud from English club Coventry City despite knowing that the striker would be able to move for free in January 2007 as his contract was due to run out at the end of December.

Mifsud made his début for Coventry City on 13 January 2007 in a Football League Championship match at home to Crystal Palace.

Furthermore, Blackpool's Kaspars Gorkšs was shown the red card for a foul on Dele Adebola, after a Mifsud through ball.

[14] On 12 November, Mifsud was sent off after 11 minutes of a Midlands derby against West Bromwich Albion, after elbowing Carl Hoefkens in the face.

[18] On 5 January 2008, Mifsud scored two goals in the FA Cup in Coventry City's defeat of Premier League Blackburn Rovers at Ewood Park.

On 29 July 2008, Bristol City announced that, following negotiations, in which manager Gary Johnson questioned Mifsud's commitment, they would not be proceeding with his signing.

On 30 June 2009, Mifsud's Coventry City contract expired and he was subsequently released after becoming surplus to requirements by manager Chris Coleman.

Mifsud reportedly received interest from Chicago Fire of Major League Soccer in America,[26] Benfica, from various clubs in the Italian Serie B and was even offered a contract by AEK Larnaca, besides being linked with a possible return to Valletta.

Included in this was a strike in Valletta's 3–0 defeat of former club Sliema Wanderers on 29 April, to secure his side's 21st national championship.

On 22 November 2014, Mifsud re-opened his scoring account with Sliema Wanderers with a 63rd-minute goal against Tarxien at Victor Tedesco Stadium.

On 20 January 2016, it was announced that Mifsud would be returning to Valletta on a free transfer after signing a two-and-a-half-year contract with the club.

[38] His spell with the San Pawl il-Baħar's side only lasted few months: in January 2021 Mifsud parted way with Sirens for personal reasons.

On 27 March 2008, Mifsud scored five goals for Malta in a 7–1 friendly win over Liechtenstein, completing a hat-trick within just 21 minutes of the kickoff.

[40] On 3 March 2010, he surpassed Carmel Busuttil's goalscoring record with the national team, as Mifsud hit the back of the net for Malta in an exhibition match against Finland, which finished in a 1–2 loss for the locals.