He played college football at USC, where he was named a consensus second-team All-American as a senior, and was selected by the Colts in the second round of the 2020 NFL draft.

As a senior, He caught 81 passes for 1,990 yards and 24 touchdowns and was named first-team All-America by Parade and Max Preps and participated in the All-American Bowl.

[2] Rated a four star recruit, Pittman initially committed to play college football for the UCLA Bruins.

[6] Pittman caught 10 passes for 232 yards (5th-most in a game in USC history) and a touchdown in a 30–23 win over tenth-ranked Utah on September 20, 2019.

[7] Pittman finished the season with 101 receptions for 1,275 yards and 11 touchdowns and was named first-team All-Pac-12 and a consensus second-team All-America selection.

[12] Pittman made his professional debut on September 13, 2020, against the Jacksonville Jaguars, catching two passes for ten yards in the 27–20 loss.

He had his first 100-yard game with seven receptions for 101 yards in the 34–17 victory against the Tennessee Titans in Week 10 on Thursday Night Football.

[19] In a Week 2 loss against the Los Angeles Rams, Pittman had a career game, hauling in 8 passes for 123 yards.

[21] Continuing to carve out a big role in the Colts' offense, Pittman hit 100 receiving yards for the third time in his career in a Week 7 Sunday Night Football matchup against the San Francisco 49ers.

[22][23] In the following week's overtime loss against the Titans, Pittman recorded 10 receptions on 15 targets for 86 yards, also scoring 2 touchdowns within a minute.