[7] Coote returned to Australia in 2001 and joined the Research School of Chemistry, Australian National University as a postdoctoral fellow with Leo Radom.
It was during this time that she began to build a reputation in computational chemistry, and she established an independent research group on the computer-aided chemical design[8] at ANU in 2004.
Awarded an ARC Future Fellowship in 2010, Coote focused on a computer-guided experimental approach to understand and control the stereochemistry of free-radical polymerisation.
[11] Today, her research interests span several broad areas of fundamental and applied chemistry: stereocontrol in free-radical polymerisation,[12] polymer degradation and stabilisation,[13] radical stability[14] and, most recently, electric field effects on chemical reactivity.
[21] She was elected a Fellow of the Australian Academy of Science in 2014 for developing and applying accurate computational chemistry for modelling radical polymerization processes.