As the drum rotates the spheres inside collide with the particles of the solid, thus crushing them towards smaller diameters.
Crushing employs hammer-like tools to break the solid into smaller particles by means of impact.
These methods use supercritical fluids to induce a state of supersaturation, which leads to precipitation of individual particles.
[2] Parameters like relative pressure and temperature, solute concentration, and antisolvent to solvent ratio are varied to adjust the output to the producer's needs.
These adjustments can lead to the nucleation of particles of varying sizes by polymorphic or amorphous transformations, as well as due to the characteristics of aggregation processes, which in some cases is accompanied by changes in conformational equilibria.
[6][7][8] Because of the relatively low pressure involved, many supercritical fluid methods can incorporate thermolabile materials.
This phase change severely decreases the solubility of the mixture and results in precipitation of particles.
[12] In the PGSS method (Particles from Gas Saturated Solutions) the solid material is melted and the supercritical fluid is dissolved in it.
The PGSS method has the advantage that because of the supercritical fluid, the melting point of the solid material is reduced.
Compounding pharmacies can supply micronized progesterone in sublingual tablets, oil caps, or transdermal creams.