The confluence with the South Fork is 41 miles (66 km) by water to where the main stem of the Coquille River enters the Pacific Ocean at Bandon.

[4] The land in the watershed is used mainly for timber production and farming; commercial forests dominate much of the region.

[3] Named tributaries of the Middle Fork Coquille River from source to mouth are Estes, Lake, Cole, Lang, Wildcat, Bar, Reed, and Jim Bilieu creeks.

[4] The Middle Fork supports populations of wild cutthroat trout as well as small runs of salmon and steelhead.

The river is closed to fishing between mid-September and the end of November to protect spawning salmon.