Middleburg High School has a diverse athletic scene with large participation from students in Cheerleading, Golf, Tennis, Basketball, Soccer, Track, Cross Country, Dance, Swimming, Wrestling, Football, Baseball, Slow and Fast-Pitch Softball, Academic Team, Marching Band, Weight Lifting, and NJROTC Athletics Team.

Middleburg High's extracurricular activities range widely from the traditional Health Occupations Students of America (HOSA), National Honor Society, and chorus to less conventional clubs such as anime.

Middleburg High features the ‘Bronco Book Club’ as a way to encourage reading amongst its students and executive boards for each class (i.e.

Middleburg also has a Health Students of America chapter which attends state competition yearly.

The school also has an active SkillsUSA chapter, in which students compete on the regional, state, and national level in trade-related events.