Middleton is situated on the banks of the Fish River off the N10 road and is about 30 km south of Cookhouse.

Middleton is located near Cookhouse and was first established in 1879 as a train station to act as a layover point between larger towns.

At the turn of the 20th century, the Middleton complex was developed by Mr George Webster, a blacksmith by trade.

At the time Middleton comprised a hotel, smithy building, general dealer’s shop, church school and 500 morgen of veld.

The Addo Elephant National Park and a number of private game reserves are less than an hour's drive south along the N10 highway from Middleton.