Mill Creek is a tributary of the Susquehanna River in Luzerne County, Pennsylvania in the United States.
Shortly afterwards, it crosses under Interstate 81 and Pennsylvania Route 315 and turns southwest again, roughly skirting the border between Plains Township and the city of Wilkes-Barre.
A short distance downstream of Pennsylvania Route 309, it reaches its mouth at the Susquehanna River.
[6] The water quality of Mill Creek decreases downstream of its confluence with Gardener Creek, but increases downstream of its confluence with Laurel Run, due to a Concentration#Qualitative descriptiondilution effect.
[6][7] The middle reaches of Mill Creek experience erosion near Bald Mountain Road.
The lowest elevation in the watershed is 530 feet (160 m) above sea level at the confluence of the creek with the Susquehanna River.
[3] The highest elevation is 2,160 feet (660 m) above sea level on the tops of ridges on the southeastern edge of the watershed.
[7] The Mill Creek watershed is in the Appalachian Mountain section of the ridge and valley physiographic region.
[7] The Red Ash coal seam is found in the Mill Creek watershed.
[3] The Oquaga-Wellsboro-Lackawanna soil association is found in the upper reaches of Mill Creek as well as in the southwestern part of the watershed.
[3] Forest occupies 26.24 square miles (73.17%) of the Mill Creek watershed, making it the largest land use.
[3] A small sawmill was built by the Pennamite settlers near the mouth of Mill Creek in spring 1771.