The brewery was named after its original location at 55 Mill Street in the historic Distillery District, the former industrial complex occupied by spirits maker Gooderham and Worts.

In early 2006, all large-scale brewing was moved to a bigger facility in Scarborough, Ontario, and the Distillery District location reopened in October, 2006 as a brewpub.

In 2007, co-founder Michael Duggan felt the company was diverging from its original vision, and left to start his own brewery.

[1] In 2011, the company leased a historic grist mill building adjacent to the Chaudière Falls in Ottawa[2] and converted it into a brewpub.

As part of the purchase agreement, Labatt agreed to invest $10 million into brewing operations to help expand into Quebec.