It originates above Gerber Reservoir and empties into irrigation canals within Langell Valley southeast of Bonanza and finally into the Lost River.

Miller Creek has spatial variability in temperature thresholds, especially observed in the lower 4.7 miles (7.6 km) of the stream.

[3] The name honors James Miller (1814–1890), an Irishman who came across the continent in 1844 with the Stephens-Townsend-Murphy Party[4] and settled on part of Rancho San Pedro, Santa Margarita y Las Gallinas in 1845.

[5][6] Although not well documented or understood, in recent years, Columbia River redband trout (Oncorhynchus mykiss gairdneri) have been identified in Miller Creek.

The creek has been identified by the E.P.A., Klamath County Public Works, and the Oregon Department of Fish and Wildlife for trout restoration potential because the creek has high-quality, connected riparian habitat; minimal barriers to fish passage; and flow is subject to the operation of Gerber Dam.