Parts of the river demarks the border between Middlesex and Mercer Counties, which also forms the boundaries between the Second and Third Districts of the Federal Reserve.
It receives Royce Brook before flowing past the Somerset Christian College, one of the few structures built on the land between the D&R Canal and the Millstone River.
The Millstone River basin has suffered a number of severe flooding events over the past 200 years.
[4] The Millstone River provides drinking water to tens of thousands of households and businesses in Central New Jersey.
In general, the stage coach took a bee-line route, straight as the crow flies, between the Raritan Bay at South Amboy and the Delaware River at Bordentown.
As the country grew and its economy began to thrive, large buoyant barges supported by water on canals emerged as much more suitable for heavy shipping.
Hence the importance of the Millstone River which provides a north–south waterway through New Jersey connecting the two great cities of Philadelphia and New York.
The land between canal and river is a flood plain that generally consists of swamps, wooded areas and some farmland.
In Lawrenceville, New Jersey, at a site known as Bakers Basin today located along U.S. Route 1, the canal makes the few mile remaining connection into Trenton, the state capital, and then into the Delaware River.
Hence the Millstone and Raritan Rivers enabled the major shipping route between New York and Philadelphia in the early 19th century.