The bridge connects the Middlesex County communities of Woodbridge Township on the north with Sayreville on the south.

The bridge was closed for reconstruction,[5][6][7] to allow for the installation of a third column built on the 1955 piers in addition to a fully divided roadway deck.

Work was completed in 1972, at which point the bridge was converted to serving ten lanes of traffic total.

[8][7][5] The bridge was formally renamed in 1974 for former Governor Alfred E. Driscoll, who advocated for and oversaw the construction of the Garden State Parkway and New Jersey Turnpike.

[13] The speed limit on the Garden State Parkway was 45 miles per hour (72 km/h) approaching and traversing the Driscoll Bridge.

[15][16] On February 17, 2010, Shamshiddin Abdur-Raheem was sentenced to life in prison for the murder of his daughter by throwing her off the bridge.