Milo Center is an unincorporated community in Deaf Smith County, in the U.S. state of Texas.

[1] According to the Handbook of Texas, the community had a population of 5 in 2000.

Milo Center is located on U.S. Route 385, north of Hereford in east-central Deaf Smith County.

[2] Milo Center joined the Hereford Independent School District in 1939.

[2] Today, the community is zoned for Bluebonnet Elementary School.