After the intersection with Round Lake Road, SR 46 turns northeast and runs parallel to an abandoned railroad line, which it then curves away from, but then encounters at a former grade crossing in Sorrento just west of the intersection with County Road 437, which shares a brief concurrency with SR 46 for several blocks.

Before entering the forest however, SR 46 passes by Mount Plymouth Lake to the south, intersecting County Road 46A at an at-grade intersection and the current northern terminus of State Route 429 at a modified diamond interchange, merging onto the latter's future alignment.

Here, State Road 46 also encounters the same right-of-way for the abandoned railroad to the north, which runs parallel to the road as even after it leaves the forest on a bridge over the Wekiva River at the Lake-Seminole County line becoming North Henderson Lane, and running along the south end of Lower Wekiva River Preserve State Park.

SR 46 runs along the northern border of the Orlando Sanford International Airport, then after the southern terminus of State Road 415, uses a bridge over Lake Jesup at the St. Johns River then become Geneva Avenue as it heads southeast.

East of Geneva, the road crosses the St. Johns River itself using the Mims Bridge south of Lake Harney, and entering Volusia County.

The intersection at the western terminus of State Route 46 and US 441 was previously a diamond interchange, but was downgraded as part of the Wekiva Parkway project.