After the Rock Island extended its railroad track to the Chisholm Trail, the town physically moved to the end of the rail line and renamed itself Minco.

There was a road established in 1839-1840 on the north side of the Canadian River, that was also named the Fort Smith to Santa Fe Trail.

During the summer of 1853, the first railroad survey was conducted from Fort Smith to Los Angeles by Lt. Amiel Weeks Whipple.

Whipple continued westward, leaving Oklahoma just west of the Antelope Hills in present-day Roger Mills County.

On August 4, 1901, the Chickasaw Nation's land was opened to white settlement, making Minco a railroad hub for the entire region.

[9] On October 14, 1901, local citizens formed a company for the purpose of selling vacant lots in the town to encourage settlement.

[9] Minco was originally composed mainly of merchants who provided supplies for the many travelers that used the railroad infrastructure of the town.

[9] In September 1894 Meta Chestnutt, a teacher from North Carolina who was determined to bring education to the frontier, specifically to Native Americans, along with the services of J.H.

Having faced economic troubles for the whole of its existence, it was decommissioned in 1920 due to decreasing enrollment after the arrival of newer educational institutions that came with statehood.

After the demolition of the old school building, a modern masonry armory was constructed in 1936 and today serves as a community gathering center.

[10] In 1960, the first municipal natural gas company in Oklahoma was founded in Minco by James Burton Branum, Jr.

It operated along with the Minco Tag Agency from an office in the back of what was then Branum's Variety Store on Main street.

It is based on the town having a large number of dairy farmers and Oklahoma's largest beekeeping company, Gibson-Ross Clover Bloom Honey.

In 2017, the wind farms generated 300 megawatts of electricity,[16] some of which is used to power Google's Mayes County, Oklahoma facility.

Minco's earlier newspapers and years of publication since origin are as follows: Microfilm copies of these papers are available at the Oklahoma Historical Society building, south of the state capital, on the second floor.