[4] Beynon was influenced to create Mindbloom through his family's history of mental illness and his own positive experiences with psychedelic medicines.

[6] In March 2020, Mindbloom opened an in-person clinic on New York's Fifth Avenue, which was described in a Forbes article as the city's "first legal, upscale guided psychedelic therapy center".

[7] Not long after the center's opening, the governor's office of New York issued the PAUSE order in response to the severity of the COVID-19 pandemic, closing all non-essential businesses,[8] causing the company to pivot back to a remote model.

[9] In 2022, it was reported in The Wall Street Journal that Mindbloom had hired former House representative Greg Walden for the purpose of lobbying on telehealth policies.

[13][2] In addition to the medicine, patients are shipped a sleep mask, journal, and blood pressure cuff to monitor their vitals before and after a session.

[14] Through the company's mobile app, patients can reach out to clinicians during their treatment, or, access "interactive educational content for use before or after" their sessions.

[3] In 2022, a study was published in the Journal of Affective Disorders, testing the effectiveness of at-home ketamine therapy for treating depression and anxiety, using data from 1,247 Mindbloom patients.