These Appalachian foothills of southeastern Ohio, especially in nearby Shawnee State Park and Forest, have been nicknamed the "Little Smokies".

Minford's weather is characterized by warm humid summers, cold wet winters, with brisk temperate spring and fall seasons.

However, the Minford Local School District covers most of Madison and Harrison townships, including places of different ZIP codes.

Other ZIP codes in Harrison and Madison Townships include 45648 (Lucasville), 45662 (Portsmouth), and 45694 (Wheelersburg).

It becomes SR 728 in Valley Township near the Southern Ohio Correctional Facility to the road's terminus at US 23.

High Street is a subsidiary route that carries truckers and commuters from SR 335 to Lucasville-Minford Road in Mule Town.

[7] However, the original building is no longer standing; a new post office was recently constructed at that location in 2000.

Currently, the phone company is offering cable television services and fiber optic internet.

There are two interchanges in Minford: one near the Greater Portsmouth Regional Airport on State Route 335, and one on Lucasville-Minford Road near Rases Mountain Drive.