The first academic center was founded by Dominican friars in 1518 and it would later be elevated to a university by the papal bull In Apostolatus Culmine of October 28, 1538.

[5] Higher education was restored on 1815 by writer and politician José Núñez de Cáceres, who was elected rector of the institution.

The origin of the Ministry of Higher Education, Science and Technology comes from the Commission to Reform and Modernize the Nation (Comisión para la Reforma y Modernización del Estado) from 1966.

This commission concluded that it was a necessity to create an institution that could manage the scientific and technological activities, as well as everything relating to higher education and universities.

[6] It adopted its current name, Ministry of Higher Education, Science and Technology (Ministerio de Educación Superior, Ciencia y Tecnología), after the 2010 Constitutional reform and the subsequent Decree no.