The school serves the Mira Mesa community as well as students participating in the district's Voluntary Enrollment Exchange Program (VEEP).

[8] Mira Mesa High School's Athletics programs include: Football, basketball, field hockey, waterpolo, swimming, baseball, soccer, tennis, cross country, dance, volleyball, badminton, softball, wrestling, lacrosse, track and field etc.

The Mira Mesa Boys Wrestling team has won thirteen consecutive League Titles (2012-2024) and 24 overall.

The team has also won thirteen consecutive San Diego City Conference (Willie Jones Jr. Memorial) Titles (2012-2024) and 21 overall.

[10] Mira Mesa High School offers a wide variety of AP and Honors classes.

Mira Mesa High School offers several language programs, including Spanish, French, and Filipino.

Mira Mesa High School's marching band, the Sapphire Sound, performs in field and parade competitions throughout Southern California in the fall.

The Sapphire Sound is the largest band in San Diego Unified School District, with over 200 students.

The Wing has a friendly rivalry with Herbert Hoover High School's Army JROTC Group.