There are active peat extraction sites and polders on the banks of the river from the village of Stelpe to Beibeži.

From the Zvirgzde river to the village of Plakanciems there are several summer cottage colonies on the wooded banks of the Misa.

Below Plakanciems to the Misa's confluence with the Iecava near Ozolnieki, the land either side of the river has a relatively high population density.

The biggest settlements near the river are: Stelpe, Beibeži, Dzērumi, Plakanciems, Pēternieki, Dalbe and Ozolnieki.

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