Mississippi's 1st congressional district is in the northeast corner of the state.

It includes much of the northern portion of the state including Columbus, Oxford, Southaven, Tupelo, Olive Branch, and West Point.

The district includes Alcorn, Benton, Calhoun, Chickasaw, Choctaw, Clay, DeSoto, Itawamba, Lafayette, Lee, Lowndes, Marshall, Monroe, Pontotoc, Prentiss, Tate, Tippah, Tishomingo, Union, Webster, and a portion of Oktibbeha County.

The congressional seat has been held by Republican Trent Kelly who won a June, 2015 special election to fill the vacant seat previously held by Republican Alan Nunnelee who died February 6, 2015.

In the November 2010 election, Nunnelee had defeated Democratic incumbent Travis Childers, Constitutionalist Gail Giaramita, Independent Conservative Party candidate Wally Pang of Batesville, Libertarian Harold Taylor, and Reformist Barbara Dale Washer.