On January 24, 1826, the college received its first charter, signed by Mississippi Governor David Holmes.

That year it granted degrees to two women, Alice Robinson and Catherine Hall.

[10] In May 1992, MC absorbed Clarke College after the smaller school was forced to close due to declining enrollments.

Throughout the 1990s, the college renovated and expanded; work was carried out on the library, electronic media center, Cockroft Hall (for the School of Nursing), A.E.

[10] Mississippi College was granted an exception to Title IX in 2015, which allows it to legally discriminate against LGBT students for religious reasons.

During the Civil War, U.S. General Ulysses S. Grant used it as a hospital for his wounded troops and reports say it was also used as a stable for his horses.

Built in 1948, Nelson Hall serves as the university's administration building and contains Swor Auditorium, the venue for musical performances.

Wood Coliseum is used for MC Choctaws basketball games and is the site for university graduations.

The Leland Speed Library houses its Learning Resources Center which includes studios for the Department of Communication.

The 8,500-seat Robinson-Hale Stadium is the home field for MC Choctaws football games and track meets on the Clinton campus.

[19] The MC Dyslexia Center was expanded in January 2019 to include additional rooms to evaluate children with the learning disability, and other offices.

With an enrollment of 850 students, business is the single largest undergraduate major on campus.

The MC School of Law serves more than 400 students on East Griffith Street in downtown Jackson.

[14] Mississippi College competes in NCAA Division II as a member of the Gulf South Conference as of 2014.

[26] The MC men's baseball team won the 2018 Gulf South Conference championship.

[28] In Fall 2018, the women's soccer team finished the season ranked 14th in the nation.

[29] From 2012 through 2014, MC's table tennis team ended the season ranked second of the 250 participating universities.

[30] The MC table tennis team finished the 2017–18 season ranked third in the nation at the championship games in Round Rock, Texas in April 2018.

The university's bass fishing and sporting clays squads takes part in regional and national competitions.

The men's compound team and the bowhunter women's squad won first place at the National 3D Championships in Foley, Alabama in 2018.