It travels approximately 126 miles (203 km), serving Jefferson, Copiah, Simpson, Smith, and Jones counties.

The road does share a four-lane concurrency with US 49 for about two miles (3.2 km) in the city of Magee before turning south.

The highway passes through more farmland before coming to an end at an intersection with US 84 in Calhoun, a small community on the western outskirts of Laurel.

The route already shares a two-mile-long (3.2 km) concurrency with US 49 in Magee, and some residents feel that a four-lane highway would better alleviate heavy truck traffic.

[citation needed] There have been no official plans from the Mississippi Department of Transportation (MDOT) to upgrade MS 28 to freeway standards.

Residents opposed to the potential change claim that "four-laning" the Highway would also entail bypasses for several small towns along the route, stifling business opportunities.