Mississippi Highway 328 (MS 328) is an east-west state highway located entirely in the Yocona River valley of the North Central Hills in northern Mississippi, connecting MS 315 to Markette at MS 7.

The state highway serves the town of Taylor (via MS 733, a.k.a.

It winds its way northeast through hilly woodlands for a couple miles before traveling due east as it enters the Yocona River Valley.

The highway travels along the northern banks of the river as it passes through farmland for several miles, where it makes a sharp left turn at an intersection with Marshall County Road 387 (CR 387, provides direct access to the town of Water Valley).

MS 328 now also becomes known as Cotton Road as it travels along the southern edge of the town of Taylor, with access to the town provided via MS 733 (Main Street) and Cutoff Road.