[1] MS 330 begins in Yalobusha County at an intersection with US 51 on the western outskirts of Tillatoba.

It heads east to pass directly through the center of the small town, where it makes an odd sharp left turn before crossing a railroad track, only to leave Tillatoba shortly thereafter at an interchange with I-55 (Exit 220).

The highway now winds its way through a hilly, remote, and wooded tract of the Holly Springs National Forest for the next several miles, passing through the Tillatoba Lake Recreation Area (and along the coastline of the lake itself).

The highway leaves Coffeeville, after crossing two bridges over two very large creeks, and heads southeast across some hilly woodlands to enter the Skuna River valley at the eastern end of the northern arm of Grenada Lake, where it has an intersection Elam South Road (former MS 335) in the community of Gums.

It heads along the northern banks of the river for a couple miles to enter Calhoun County.