MS 403 ends at the intersection of Clarkson Road and Old US 82 near a county highway maintenance barn.

The route was designated by 1960, after a paved road extending from Mathiston was constructed around 1958.

The route travels through a forested area within the town and intersects East Weber Drive south of the city limits.

MS 403 turns east at the intersection, traveling along Old US 82 and through an underpass at the parkway.

[3] Around 1958, a paved road was constructed from Mathiston to a point 1.3 miles (2.1 km) north of the town.