[1] The highway starts at its intersection with US 49 and North Swan Road in northern Gulfport.

The road travels westward towards the unincorporated area of Lyman after crossing over a KCS Railway railroad.

[7] At Herman Ladner Road, the highway turns westward and crosses the Wolf River, entering Hancock County.

MS 53 turns northward at the intersection, and shifts westward at Dogwood Lane, south of the county line.

[4] Once inside Pearl River County, the road intersects multiple private driveways through the farmland.