It travels southeastward through George County, crossing over Escatawpa River.

[4] It travels eastward and crosses the Mississippi Export Railroad shortly.

At Red Creek Church Road, MS 612 travels southeast into a larger forest.

[3] After its intersection with Will Howell Road, MS 612 turns eastward and begins travelling in a straight line.

[4] The route ends at the Mississippi–Alabama state line, and County Road 7,[5] also known as Natchez Highway, continues into Mobile County to connect with US 98 just west of the town of Wilmer.