On August 29, 2005, Moss Point was hit by the strong east side of Hurricane Katrina, and much of the city was flooded or destroyed (see details below).

Moss Point is home to Trent Lott International Airport and the Mississippi Export Railroad.

It is bordered to the south by the city of Pascagoula, the county seat, and to the north by unincorporated Escatawpa.

On August 29, 2005, Moss Point was hit by the strong eastern side of Hurricane Katrina, when it passed 30 miles (48 km) east of central New Orleans with minimal gale-force winds.

However, on the east side of Hurricane Katrina, much of Moss Point was flooded or destroyed in one day, by the strong hurricane-force winds which lasted several hours and a storm surge exceeding 20 feet (6.1 m) in some sections.