Route 154 is a highway in northeastern Missouri.

Its eastern terminus is at U.S. Route 54 north of Vandalia; its western terminus is at U.S. Route 24) west of Paris, where Business US 24 also has its western terminus.

Route 154 passes through Mark Twain State Park and over Mark Twain Lake.

The part east of Perry became an extension of Route 19 in about 1930, and the rest was renumbered Route 154 by 1946.

This Missouri road-related article is a stub.