Route 267 begins at an intersection with US 50/US 61/US 67 in Mehlville, St. Louis County, heading northeast on four-lane divided Lemay Ferry Road.

From the southern terminus, the route heads through business areas, becoming a five-lane road with a center left-turn lane.

Route 267 loses the center turn lane and continues through suburban areas of homes and commercial establishments.

Straight ahead lies Alabama Avenue, which crosses over the River des Peres to continue north into the city.

A short distance later, Route 267 turned southeast onto four-lane divided Marceau Street and passes through residential areas, eventually terminating at an intersection with Broadway.