Missouri Route 269 is a highway in the Kansas City metropolitan area.

Chouteau Trafficway is very narrow for its amount of traffic, so in mid-2011, all buildings on Chouteau Trafficway between NE Parvin Road and NE Winn Road were taken by eminent domain and razed to widen Route 269 into a four-lane boulevard.

Route 269 begins at an intersection with Front Street in Kansas City, Jackson County, heading northwest on four-lane undivided Chouteau Trafficway.

Past this interchange, Route 269 heads back into Kansas City, Missouri and becomes a two-lane undivided road, passing businesses.

The route continues north through residential and commercial areas, then widens into a four-lane divided highway and reaches its northern terminus at an interchange with I-35.