Its southern terminus is at Route 80, and it travels north through farmland to the town of Anniston.

It then travels westward to its northern terminus at Route 105 north of East Prairie.

[1] In 2015, the Missouri Department of Transportation (MoDOT) measured about 796 vehicles, including 66 trucks, traveling on the route near Anniston on average each day.

Route 75 turns west at B Street (CRD 339), leaving the city limits.

It then crosses over the Wolf Hole Lateral, and ends at another T intersection at Route 105, south of the Mississippi County Airport.