In the west, Route 98 begins at Business Loop Interstate 70/Route 87 in Booneville.

It proceeds eastward, traversing a largely rural area.

Upon reaching Orchard Drive, Route 98 turns due south, but soon resumes an eastward course as it passes near the Jesse Viertel Memorial Airport.

The highway approaches I-70, which it generally parallels for its entire length.

It turns northeast and loses its designation at a railroad crossing and transitions into Cumberland Church Road, south of the Missouri River.