[1] The creek rises on the Taylor Range and runs in a south-easterly direction from the southern edge of Brisbane Forest Park in Kholo and Pullenvale, flowing through Upper Brookfield, Brookfield and joining the Brisbane River at Kenmore.

Before entering the Brisbane River the creek is crossed by Moggill Road and winds through Rafting Ground Reserve.

Aboriginal naming of Moggil Creek comes from their description of the large water-lizards that were hunted and eaten in the area.

[2] There are various land uses within the Moggill catchment, including commercial and residential areas, grazing and natural bushland.

The natural habitat is being restored by the Moggill Creek Catchment Group and the Brisbane City Council Wildlife Conservation Partnership program.