Syedna Mohammad Ezzuddin (Arabic: محمد عزالدين, romanized: Muḥammad ʿIzz al-Dīn) (died 1539 / 27th Safar, 946 AH in Zabid, Yemen) was the 23rd Da'i of the Dawoodi Bohra, a sub-sect of Isma'ili Shi'i Islam.

Syedna Mohammed was the 17th Da'i from Ale Waleed and the last of Du'āt Mutlaqūn from Yemen.

He resided in Masar but had to leave due to the immense atrocities of the Zaidi Imam Al-Mutawakkil Yahya Sharaf ad-Din.

He had to submit the fortress of Masar to the Zaidi Imam after the wafāt or demise of Syedi Hasan bin Nuh.

Syedna Mohammed Ezzuddin replied that “The letter will reach Yusuf Najmuddin and he shall become Da'i al-Mutlaq”, and it did happen.