[1] They were from Six Nations, along with some from the New Credit, and Moraviantown, Sarnia, Walpole Island, Muncey, Scugog, Stoney Point, Saugeen, Bay of Quinte and Kahnawake reserves.

The new school building contained separate boys and girls wings, principal's and teachers quarters, as well as administrative offices.

[2] In 1922, management of the school was formally taken over by the Canadian government, though the New England Company retained ownership, and the agreement required that the principal be Anglican.

[3] Students frequently ran away from the Mohawk Institute, so the staff built a prison cell to hold captured runaways in the basement.

One former student, Lorna, who attended the Mohawk Institute from 1940 to 1945, recalled being given shock treatment for wetting the bed.

"They used to bring in a battery—a motor of some sort or some kind of gadget, and he’d put the girl’s hand on it and it would jerk us and it would go all the way through us from end to end—it would travel.

Sally also remembered being locked in a dark room with her friend and being told by staff that "the rats were gonna get us".

[10] In 2013 a leak in the roof of the residential school building caused significant damage to the historic site.

[9] Following the 2021 discovery of previously unknown burials at the Kamloops Indian Residential School in British Columbia, Six Nations of the Grand River chief Mark Hill called on the Canadian federal government to support a search for missing children who could have been buried on the Mohawk Institute's grounds.

[14] The history and student experience at the Mohawk Institute has contributed to the works of a number of authors and artists including: