Moores Bluff is a ghost town in Lowndes County, Mississippi, United States.

Located on the west bank of the Tombigbee River, the town was an important trading point for cotton during the early history of the county, and shipping receipts have been located from the early 1840s.

Two large brick warehouses were located there, and thousands of bales of cotton were shipped annually by boat from Moores Bluff.

[2]: 282 The construction of the Mobile and Ohio Railroad in the 1890s greatly reduced shipping along the river, and the town became extinct.

[2]: 282 Moores Bluff is today located on an uninhabited and inaccessible point in the river.