Plymouth was an early settlement in Mississippi in present-day Lowndes County.

Plymouth was located on the west bank of the Tombigbee River at the mouth of Tibbee Creek.

[3] Local tradition holds that Hernando de Soto camped near the site Plymouth and Jean-Baptiste Le Moyne de Bienville erected a fort here in his campaign against the Chickasaw.

[4] The community of Plymouth was formed around 1819, developing around the fortified house of John Pitchlynn, the U.S. interpreter for the Choctaw Agency.

[7] Today, the site of Plymouth is just west of John C. Stennis Lock and Dam on the Tennessee-Tombigbee Waterway.