After the company went under during the dot-com bubble burst of 2000, her friend Catherine Schwartz got her hired at TechTV in 2001, and Webb became employed as the associate producer and web researcher for The Screen Savers.

Examples included a recap of the annual TED Conference,[8] a viral video special showcasing "future 'Darwin Award' winners",[9] and tech-centric "Holiday Buyer's Guides".

[10] In January 2009, Webb suspended WebbAlert indefinitely due to issues with maintaining it on a daily basis concurrently with her hosting duties on X-Play.

[11] On February 25, 2009, G4 announced that Webb would be the host of their new show G4 Underground, a weekly series that profiles a wide range of people and topics that are of interest to the "internet generation".

[16] As an infant and small child, Webb appeared in advertisements for Gerber baby food, Kenner Toys, and an ad for McDonald's, where she recited the ingredients of the Big Mac to a game of Pat-a-cake.

Webb won the poll and was offered a nude photo shoot, but she refused, despite being "very flattered", citing her own personal reasons and her parents' objection to the idea.

[20] She makes her appearance near the end of the video alongside other fellow TechTV personalities, including Catherine Schwartz, Sarah Lane, Laura Swisher, Chi-Lan Lieu, and Sumi Das.

[22] On June 21, 2008, Webb along with her X-Play co-host Adam Sessler, participated in the 50th annual Hollywood Stars Celebrity Softball game at Dodger Stadium.

[23] A YouTube video was posted on October 7, 2013, with Webb as the well-versed host of a "Patch 5.4 Developer Round Table" discussion with Blizzard Entertainment employees J. Allen Brack, Ion Hazzikostas, and Tom Chilton.

[24] Webb played a minor role as Neely Lamm on the CBS TV Drama series Bull on an episode titled, "The Fall" which aired on February 7, 2017.