Cities and towns are marked in bold: Bečov - Bělušice - Braňany - Brandov - Český Jiřetín - Havraň - Hora Svaté Kateřiny - Horní Jiřetín - Klíny - Korozluky - Lišnice - Litvínov - Lom - Louka u Litvínova - Lužice - Malé Březno - Mariánské Radčice - Meziboří - Most - Nová Ves v Horách - Obrnice - Patokryje - Polerady - Skršín - Volevčice - Želenice Most District borders Germany in the north.

The territory extends into three geomorphological mesoregions: Most Basin (southwest and centre), Ore Mountains (north) and Central Bohemian Uplands (southeast).

The highest point of the district is the mountain Loučná in Lom with an elevation of 956 m (3,136 ft), the lowest point is the river bed of the Bílina in Želenice at 204 m (669 ft).

Notable is also Fláje Reservoir with an area of 153 ha (380 acres).

The most important road that passess through the district is the I/13 from Karlovy Vary to Liberec.