On February 1, 1964, the new convent was officially moved into with the 1964 school year consisting of two priests and five sisters serving as faculty for 215 students.

Homemaking, Art, Music, Drivers Ed, and business programs were expanded with the first visit to Emmitsburg being hosted that year, a trip to honor Mother Seton, the school's patron.

In 1979, the Middle States accreditation was extended for 10 additional years and, in 1981, the New Jersey Department of Education reviewed and updated Mother Seton Regional High School's facilities and curriculum.

In 1983, Mother Seton celebrated its 20th anniversary with the play The Sound of Music and a symposium covering the school's previous 20 years.

[5] In 1987, Mother Seton Regional High School entered into the Greater Middlesex County Athletic Conference, and saw expansion to their administrative departments.

The Seton Leadership Team was founded in 1995, a student ambassador program that would receive press coverage from Dana Tyler for their work in aiding in Pope John Paul II's Papal Mass in Giants Stadium.

Mother Seton saw increased security measures and updated policies, with further discussion alongside the Archdiocese of Newark on future protocols.

[7] That same year, students and faculty participated in a nationwide protest against gun violence, honoring the 17 victims of the Marjory Stoneman Douglas High School shooting in Parkland, Florida.

[8] Mother Seton Regional High School offers a four-year college preparatory curriculum, and the academic program provides emphasis on math and science.

[5] The Mother Seton Regional High School Setters[2] compete in the Greater Middlesex Conference, which operates under the supervision of the New Jersey State Interscholastic Athletic Association.

[10] Sports offered include: Soccer, Tennis, Volleyball , Bowling, Basketball, Swimming, Softball, Track and Field, Cross Country and Golf.

Father Alan Gugliemo, a previous faculty member of Mother Seton Regional High School was named alongside 186 New Jersey priests as being "credibly accused" of child sex abuse.