Mount Lofty Ranges zone is a wine zone located in South Australia west of the Murray River that occupies the Adelaide metropolitan area north of Glenelg, extending as far north as Crystal Brook, and as far south as Mount Compass in the Mount Lofty Ranges.

The zone which encloses the Barossa zone on three sides, includes three wine regions that have received appellation as Australian Geographical Indications (AGIs): Adelaide Hills, Adelaide Plains and Clare Valley.

The Mount Lofty Ranges zone covers an area of central South Australia bounded at the north by a line of latitude approximately in line with Crystal Brook, to the west by the Gulf St Vincent coastline and a line extending north from Port Wakefield, to the south by the line of latitude passing through Glenelg in the Adelaide metropolitan area and the portion of the Mount Lofty Ranges extending as far south as Mount Compass and bounded to the east by a line immediately west of the alignment of Murray River.

[1][2] The term "Mount Lofty Ranges" was registered as an AGI under the Wine Australia Corporation Act 1980 on 27 December 1996.

The region received appellation as an Australian Geographical Indication in 2002 and as of 2014, it is represented by 11 wineries.