Mount Pleasant Winery was founded in 1859 by immigrant Georg Muench (1801–1879), a younger brother of Friedrich Münch.

In 1991, the owners were fined by the State of Missouri for allegedly importing an excessive amount of grape juice for inclusion in their wines.

[11] Grape varieties include Cabernet Sauvignon, Chardonnay, Chambourcin, St. Vincent, Vidal Blanc, Rayon d'Or, Merlot, Vignoles, and Norton.

Mount Pleasant has also been recognized for its practice of sustainable viticulture, an integrated system of wine grape growing that is economically viable, socially supportive, and ecologically sound.

The building runs on hydro-electric power and the structure is built partially into the ground to reduce energy consumption.