At the age of 19, while making one of his first short films, he added a soundtrack to the movie by using music from a record.

[4] In 1997, Laurent Garnier of the record label FCom bought a car from Dupieux's father.

[6] Dupieux released "Flat Beat" in January 1999, a track consisting mainly of a repeated bass loop and a drum sample from "Put Your Love in My Tender Care" by The Fatback Band.

After "Flat Beat", Oizo spent two months creating his first full album, Analog Worms Attack, which was released in 1999.

[citation needed] The record scratching effects were provided by Mr. Oizo's friend Feadz.

Released in 2005, the album was composed exclusively using computers as he had by that time decided to eschew the use of analog equipment.

The extensive time it took to remodel his studio and master the use of computers in composing electronic music is cited as the reason for the long hiatus between Analog Worms Attack and Moustache (Half a Scissor).

On 16 October 2008 his MySpace page had another video appear: a promo for his upcoming album, Lambs Anger.

Lambs Anger is Mr. Oizo's first studio album released by Ed Banger Records, the label he chose after his split with F Communications, who notoriously referred to Moustache (Half a Scissor) as "unlistenable".

Since then he has produced the following tracks for Uffie: "Dismissed", "Hot Chick", "First Love" (which charted at number 18 in Belgium[9]), "Steroids" and "MCs Can Kiss".

Mr. Oizo provided both production work and songwriting for Uffie's 2010 debut album, Sex Dreams and Denim Jeans.

He worked alongside Feadz, SebastiAn, Mirwais, J-Mat and Uffie to produce and write the album.

Unlike his previous album, The Church was released by Brainfeeder due to his activity in the United States at the time.

As he stated in an interview with XLR8R, he started using computers to avoid having to plug in four different appliances, and because the resulting music is more or less the same.

[19] Dupieux also directed the opening credit sequence for the adult animated series Moot-Moot, created by Éric and Ramzy, broadcast on Canal+ the same year.

[21] in 2013, Dupieux released the comedy Wrong Cops, featuring an ensemble cast including Eric Wareheim, Steve Little, Ray Wise, and Marilyn Manson.

[23] Dupieux returned in 2014 with the surreal comedy Reality, starring Alain Chabat, distributed in the US by IFC Midnight.

The film's story involves a commissaire de police (Poelvoorde) and a suspect (Ludig) in an interrogation room.

[27][28] In 2019, Dupieux returned with Deerskin (original title: Le daim), starring Jean Dujardin and Adèle Haenel.

[29] His film Mandibles (original title: Mandibules), starring David Marsais and Grégoire Ludig, the two members of the duo Palmashow, released on 19 May 2021 in French theaters.

The first, Incredible but True (original title: Incroyable mais vrai), was released in June 2022 in French theaters and starred Alain Chabat and Anaïs Demoustier, who respectively played in his previous films Reality and Au poste!.

[32][33] The second, Smoking Causes Coughing (original title: Fumer fait tousser), was released in November 2022 in French theaters and also featured Chabat and Demoustier as actors.

[34] In March 2023, Dupieux commented, "I am now at the stage where I can write whatever I want in the knowledge that I will find some nice people to join me on the journey.

The first, Yannick, was released in August 2023 in French theaters and starred Raphaël Quenard in the title role.

[37][38] The second, Daaaaaalí!, described as "a real fake biopic" on Salvador Dalí,[39] premiered out of competition at the 80th Venice International Film Festival,[40] and was released in French theaters in 2024.

[41] In an August 2023 interview with Le Monde, Dupieux revealed that he had completed a screenplay for a film entitled Braces.

His wife, Joan Le Boru, serves as the chief decorator and artistic director of his films.