Mycobacterial porins are a group of transmembrane beta-barrel proteins produced by mycobacteria, which allow hydrophilic nutrients to enter the bacterium.

[1][2] They are located in the impermeable mycobacterial outer membrane, or mycomembrane of fast-growing mycobacteria.

These proteins are structurally different from the typical porins located in the outer membrane of Gram-negative bacteria.

For example, the MspA protein forms a tightly interconnected octamer with eight-fold rotation symmetry that resembles a goblet and contains a central channel.

Each protein subunit contains a beta-sandwich of immunoglobulin-like topology and a beta-ribbon arm that forms an oligomeric transmembrane beta-barrel.