Muddy Creek is a 14.28 mi (22.98 km) long 4th order tributary to the Deep River in Guilford and Randolph Counties, North Carolina.

Muddy Creek rises on the east side of Archdale, North Carolina in Guilford County and then flows southeast into Randolph County to join the Deep River about 1.5 miles northwest of Randleman, North Carolina.

[2] Muddy Creek drains 26.45 square miles (68.5 km2) of area, receives about 46.3 in/year of precipitation, and has a wetness index of 418.90 and is about 24% forested.

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