Muddy Run is a 4.46 mi (7.18 km) long 2nd order tributary to Georges Creek in Fayette County, Pennsylvania.

Muddy Run rises about 0.25 miles east of Oliphant Furnace, Pennsylvania,[2] and then flows west and south to join Georges Creek at Fairchance, Pennsylvania.

[3] Muddy Run drains 5.95 square miles (15.4 km2) of area, receives about 44.2 in/year of precipitation, has a wetness index of 410.02, and is about 36% forested.

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