He twice sent tribute to the Qing government in the name of khan of Turpan, and sent an embassy to the Mughal Court in India in 1690.
The next year he dispatched an embassy to Subhan Quli, the Uzbek Khan of Bukhara (1680–1720), seeking help against "Qirkhiz infidels" (meaning the Dzungars), who "had acquired dominance over the country".
In 1693-94 Muhammad Amin Khan led an expedition against Yining, the Dzungar capital, capturing over 30,000 Kalmyks and Oirats.
The Khan was overthrown and killed during a revolt by Afaq Khoja's followers in 1694.
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